A Prospective Randomized Double Blind Study Comparing Propofol Medium Chain/Long Chain Triglyceride And Propofol Medium Chain/Long Chain Triglyceride With Lignocaine On Injection Pain
نویسندگان
چکیده
A common drawback of propofol is pain on injection and lignocaine is commonly mixed with propofol to reduce its incidence and severity. In this study we sought to compare the effectiveness of propofol medium chain and long chain triglyceride (MCT/LCT ) alone in comparison to propofol medium chain and long chain triglyceride (MCT/ LCT) premixed with lignocaine in preventing propofol pain on injection. 200 patients were randomly divided into two groups. Group A received propofol – MCT/LCT premixed with normal saline and group B received propofolMCT/LCT premixed with 20 mg lignocaine. The incidence of pain in group A was 63% compared to 15% in group B (Χ = 48.242 ,p< 0.001). To conclude propofol MCT/LCT alone provides no advantage to reduce pain on injection in comparison to propofol MCT/LCT premixed with lignocaine.
منابع مشابه
Avoiding propofol injection pain in children: a prospective, randomized, double-blinded, placebo-controlled study.
BACKGROUND Pain on injection limits the use of propofol in children. The combination of lidocaine and propofol is widely used to reduce pain. A new solvent [medium-chain triglyceride (mct)/long-chain triglyceride (lct)] has been advocated to be less painful than standard (lct) propofol in adults, but no information is available of its usefulness in pre-school children. We designed a prospective...
متن کاملDexmedetomidine pretreatment alleviates propofol injection pain
OBJECTIVE The incidence of propofol injection pain during induction of general anesthesia varies from 28% to 90%. This prospective, randomized, double-blind, placebo-controlled study evaluated the effect of dexmedetomidine (DEX) for reducing the incidence and severity of propofol injection pain. METHODS Patients undergoing elective surgical procedures were randomly allocated into seven groups...
متن کاملPain on injection with propofol
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CC The use of propofol often results in pain on injection, which is sometimes very distre...
متن کاملPharmacodynamics and pharmacokinetics of propofol in a medium-chain triglyceride emulsion.
BACKGROUND Because propofol is water insoluble, current formulations of propofol use a soybean oil emulsion. These soybean emulsions cause elevated plasma triglycerides and support bacterial growth. This study compares an alternative formulation of propofol as a 2% emulsion in a medium-chain triglyceride solution (IDD-D Propofol) with Diprivan. METHODS This double-blind, crossover, phase 1 st...
متن کاملPrevention of pain on injection of propofol: systematic review and meta-analysis.
OBJECTIVE To systematically determine the most efficacious approach for preventing pain on injection of propofol. DESIGN Systematic review and meta-analysis. DATA SOURCES PubMed, Embase, Cochrane Library, www.clinicaltrials.gov, and hand searching from the reference lists of identified papers. STUDY SELECTION Randomised controlled trials comparing drug and non-drug interventions with plac...
متن کامل